MPE-P3

MPE-P3 is a production type of Microfluidic Preparation System widely used in approved clinical mRNA vaccine projects, pre-lND nucleic acid drug projects,and FDA approved IND applications.

MPE-P3 is designed and manufactured in accordance with GMP requirements, providing a complete set of GMP validation documents. The operating system software has rich functions and can be used for continuous preparation and online dilution of LNP samples, as well as for GMP production of samples for different projects and processes. The Plc control system is equipped with a formula program that allows for flexible formulation of sample production strategies.Equipped with audit tracking function, in compliance with FDA 21 CFR part 11 requirements.

MPE-P3 supports customization, which can be customized according to different requirements such as process parameters, upstream and downstream linkage strategies, site constraints etc.

BRIEF INTRODUCTION

AlTESEN Microfluidic Preparation System is positioned for the scientific research and application of micro & nano complex injections. Through patented microfluidic chips, highly integrated and systematic hardware systems (such as delivery pump systems, PAT toolkits, etc.), and user-friendly software systems guided by process applications, we provides mature and diversified solutions for the scientific research and industrial application of different drug delivery carries such as Liposome, LNP, Microemulsion, Microcrystals, Microspheres, etc. Equipment and solutions based on AlTESEN microfluidic technology have been used in the research and industrialization of multiple clinical and marketed drugs.

Microfluidic technology has become an increasingly important technique for preparation micro & nano particles or carriers.

MPE^TM microfluidic technology and solutions are the patented technology platform Of AITESEN.which has successfully supported multiple lND and global clinical projects for nucleic acid drugs and vaccines in China and United States. The technology is mature and reliable, and we have rich customer service experience.

APPLICATION FIELD

Preparation of chemical drug liposomes, such as doxorubicin liposomes, irinotecan liposomes, etc.

Preparation of nucleic acid lipid nanoparticles, such as mRNA-LNP, SiRNA-LNP etc.

Preparation of polymer nanoparticles & microspheres, such as PLGA microspheres, PEG-PLGA nanoparticles, etc.

Preparation of emulsions, such as vaccine adjuvants, fat emulsion preparations, etc.

Preparation of organic & inorganic nanoparticles, such as gold nanoparticles, etc.

Other related micro &nano preparation products.

MICROLUIDIC CHIP

AlTESEN microfluidic chips are based on microfluidic technology, combined with the preparation principles of micro and nano formulations,specially designed and finely processed, AlTESEN's unique metal microfluidic chip, with independent intellectual property rights，meets the application needs of iner amplification and continuous production of various types of micro and nano formulations, Specially, the following four functions can be achieved：

• Mixing and emulsification of different phases
  
• Incubation after particle formation.
  
• Particle size processing after formation.
  
• Secondary mixing or emulsification.