LDS-L1

BRIEF INTRODUCTION

AlTESEN LDS series Tangential Flow Filtration system is mainly applied in the research of tangential flow ultrafiltration technology for micro & nano drugs and biological products, providing excellent technical services and solutions.

The equipment can be used for process research experiments on small-scale samples, as well as for large-scale process validation experiments.The equipment is equipped with a touch screen operating system and software programs for automatic data recording,supporting data tracing and export.The process is reliable and suitable for programmatic amplification.The components comply with pharmaceutical industry standards, they are safe and reliable.

TFF

Tangential Flow Filtration (TFF) is currently a widely used membrane separation technology. The sample is driven by pressure, and the content is separated by membrane filtration according to different molecular sizes, achieving the goals of removing heat, replacing the solution environment,purification ,and concentration.

PRINCIPLE

The implementation process of TFF is fundamentally different from dead end filtration. As the filtrate passes through the membrane components, the sample solution continuously passes through the membrane surface in a vertical direction.

MEMBRANE PARTS

The membrane components for tangential flow filtration are usually membrane packages or hollow fiber columns, both of which have multiple models to meet different usage needs. The type and pore size of membrane materials, solution circulation flow rate, pressure on both sides of membrane, sample temperature, process on both sides of the membrane，sample temperature,process time and other parameters are very important tor tangential tow filtration. They determine the final process effect, as well as the feasibility and specific plan for large-scale production. The laboratory scale tangential flow filtration equipment is committed obtaining feasible process plans plan for large-scale production. The laboratory scale tangential flow filtration equipment is committed obtaining feasible process plans effective basis for equipment or system selection.

APPLICATION FIELD

• Nucleic acid drugs and vaccines：mRNA-LNP、SiRNA、Polymer nanoparticles,etc.
  
• Chemical drug liposome：Doxorubicin hydrochloride liposomes,lrinotecan hydrochloride liposomes,Daunorubicin liposomes,Compound liposomes,etc.
  
• Solution system displacement：Replacement of buffer solution,External aqueous phase displacement of nano drug solutions,etc.
  
• Cell product separation and purification：Collection and purification of fermentation broth cells,Clarification process，etc.
  
• Plasmids,monoclonal antibodies, protein purification：Plasmid,mRNA,siRNA,etc.
  
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FLOW CHARTOF TFF