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脂质体装备

OLExS 连续式脂质体挤出仪

苏州艾特森制药设备有限公司位于苏州工业园区,是一家自主研发、专业生产及销售制药装备的科技生产型企业。

OLExS 连续脂质体挤出仪

OLExS Online Liposome Extrusion System

 

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简介 

Brief Introduction


OLExS型连续脂质体挤出仪,主要解决脂质体、纳米粒等物料颗粒大、稳定性差, 包封率低、温度要求高、原辅料贵等问题,可对样品粒子的大小和分布进行有效控制。 OLExS 型连续脂质体挤出仪具有快速操作、使用便捷、占地面积小等特点,为高校、企业脂质体研发创造有趣稳定的操作体验。

OLExS Online Liposome Extrusion System is the latest liposome extruder developed by Suzhou Aitesen Pharmaceutical Equipment Co., Ltd. It mainly solves the problems of large particle size, poor stability, low encapsulation efficiency, high temperature control requirement and high cost of raw materials and accessories. It can effectively control the size and distribution of sample particles. OLExS Online Liposome Extrusion System has the characteristics of fast operation, convenient use and small size. It creates interesting and stable operation experience for the research and development of liposome Preparation in universities and companies.

 

挤出原理

Extrusion Principle

 

脂质体挤出的原理在于,通过一定的挤出动力源将脂质体样品粒子进行挤压,使其在一定压力条件下通过PC滤膜, 此压力作为粒子过膜过程中的剪切力可使其达到粒径控制的效果。不论形态、大小和分布都可得到极大改善。

The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.

 

技术参数

Technical Parameter


型号 MODEL

OLExS-L

OLExS-Pl

OLExS-Pd

最高压力 [Mpa] Max. Pressure[Mpa]

25

25

15

最终产品粒径 [nm] 

Final Particle Size [nm]

50~1000 

50~1000 

50~1000 

单次样品量[ml] Sample Volume [ml]

5~2000 

5~3000

100~5000

最高产品浓度[mg/ml] Max. Product Concentration[mg/ml]

200 

200

200

工作温度范围 Working Temperature Range

5~80℃

5~80℃

5~80℃

产品材质 Equipment Material

SS316L 

SS316L

SS316L

动力源类型 Power Source Style

Piston Pump 

Piston Pump

Piston Pump

挤出盘直径[mm] Extruder Diameter[mm]

47

90

142

挤出盘数量 Extruder Number

2

2

≥2

最大流量(ml/min) 

Max Flow(ml/min)

200

200

>500

流量连续可调 Flow rate continuously adjustable

配有高低压保护功能 High and low voltage protection