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脂质体装备

Extru 25-20台式脂质体挤出仪

Extru 25-20台式脂质体挤出仪Desktop Liposome Extruder: Extru 25-20主要应用The main application◆阿霉素脂质体 Liposo

Extru 25-20台式脂质体挤出仪

Desktop Liposome Extruder: Extru 25-20

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25e.jpg



主要应用


The main application

阿霉素脂质体 

Liposome doxorubicin

 

 两性霉素 B 脂质体 

Amphotericin B liposome

 

 紫杉醇脂质体

Paclitaxel liposomes

 

 奥沙利铂脂质体

Oxaliplatin liposomes

 

 伊立替康脂质体

Irinotecan liposome

 

 SiRNA 脂质体

SiRNA liposome

 

 白蛋白紫杉醇纳米粒

Albumin paclitaxel nanoparticles

 

 核酸类脂质体 

Nucleic acid liposome

 

 其他整粒脂质体样品

Other whole li posome samples


挤出原理


Technical features

脂质体挤出的原理在于,通过一定的挤出动力源将脂质体样品粒子进行挤压,使其在一定压力条件下通过 PC滤膜, 此压力作为粒子过膜过程中的剪切力可使其达到粒径控制的效果。不论形态、大小和分布都可得到极大改善。

 

The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.

 

支撑板和滤板主要起到支撑滤膜的作用。 由于磷脂有一定的相变温度,所以在挤出之前需要对挤出器夹套通入恒温水进行预热至一定温度(50~60℃),且在使用过程中需保持在此温度。通常的脂质体品种挤出之后粒径能达到 100nm以下,PDI 能控制在 0.1 以下。


The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.

 

动力源:氮气

Power source: nitrogen


技术特征


Technical features

核心部件  The core components


支撑板(SS316L不锈钢)

Support plate (SS316L stainless steel)


滤板(SS316L不锈钢)

Filter plate (SS316L stainless steel)


滤膜:PC材质(聚碳酸酯)

Filter membrane :PC material (polycarbonate)


密封系统:PU材质/聚四氟乙烯

Sealing system: PU material/polytetrafluoroethylene


温控系统:夹套控温水

Temperature control system: jacket control warm water





技术特点 Technical characteristics


单次样品量少

Low sample consumption

 

压力高

High extrusion pressure

 

残留量为"0"

No residue

 

无需手动操作

No manual operation required

 

全程可控温

Whole process temperature control

 

所有部件包括“O”型圈,垫圈均通过FDA 认证 

All parts including "O" rings, gaskets are FDA approved

 

装卸方便,便于清洗和灭菌 

Easy loading and unloading, easy cleaning and sterilization

 

所有数据可直接放大 

All data can be directly amplified

 

可用于高浓度样品处理 

Can be used for high concentration sample processing

 

可放在洁净室中使用,符合 GMP 标准 

Can be used in a clean room, in line with GMP standards








型号 MODEL

Extru 25-20

最高压力 [Mpa] 

The highest pressure[Mpa]

20

最终产品粒径 [nm]

Final product size [nm]

50~1000

单批处理量[ml]

The Final product size[ml]

1~20

最高产品浓度[mg/ml]

Maximum product concentration[mg/ml]

200

工作温度范围

Operating temperature range

5~80℃

产品材质

Product material

SS316L

直径[mm]

The diameter of

25

动力源类型
Power source type

Gas




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